RENAL TUBULAR SECRETION OF POTASSIUM IN MAN 1
نویسندگان
چکیده
منابع مشابه
Renal tubular secretion of potassium in the normal dog.
During the administration ofsalyrgant (sodium salt of mercury salicyl-allylamide-ortho-acetate) to dogs, it was observed that the rate of potassium excretion frequently became constant and remained at a fixed level despite marked changes in the calculated rate ofpotassium filtration at the glomerulus. A constant excretory rate dissociated from filtered load is strongly suggestive of a tubular s...
متن کاملEvidence suggesting renal tubular excretion of potassium in man during recovery from acute renal insufficiency.
In 1942 Winkler and Smith (1), studying the simultaneous renal clearances of exogenous creatinine and potassium in dogs following the injection of potassium salts, concluded that potassium is normally filtered at the glomerulus and subjected to a variable degree of tubular reabsorption. The highest potassium/creatinine clearance ratio obtained by these authors was 0.40. In 1948 Berliner and Ken...
متن کاملRenal tubular secretion of digoxin.
SUMMARY To study the mechanism of the renal handling of digoxin, simultaneous measurements of digoxin and inulin clearances were performed in 13 digitalized patients with congestive heart disease. The renal digoxin clearances exceeded inulin clearances, indicating an active tubular secretion of digoxin. No evidence of tubular backward diffusion was disclosed. Treatment with spironolactone (Alda...
متن کاملUrinary excretion of bile acids in cholestasis: evidence for renal tubular secretion in man.
1. The apparent renal clearance of intravenously injected [14C]glycocholate and [3H]chenodeoxycholate-3-sulphate was estimated in 22 patients with cholestasis. The degree of protein binding of the isotopes in serum from these patients was determined. The effects of pharmacological agents, changes in urine flow rate and pH on renal clearance was studied. 2. The mean renal clearance of [14C]glyco...
متن کاملStereoselective renal tubular secretion of carbenicillin.
The stereoselective disposition of carbenicillin epimers was studied in healthy human volunteers. There was a difference between the two epimers in the extent of plasma protein binding in vitro, with the unbound fraction of the R epimer being greater than that of the S epimer. Renal clearance (CLR) of each epimer was greater than the glomerular filtration rate, suggesting renal tubular secretio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1949
ISSN: 0021-9738
DOI: 10.1172/jci102219